This second statement builds on the endocrine societys report of 2009, which examined the state of scientific evidence on endocrine disrupting chemicals edcs and their effects on human health. Diamantikandarakis e1, bourguignon jp, giudice lc, hauser r, prins gs, soto. Exposure to endocrinedisrupting chemicals in the usa. Endocrinedisrupting chemicals and the diabetes epidemic. In 2015 the endocrine society released a statement on endocrinedisrupting chemicals edcs specifically listing obesity, diabetes, female reproduction, male reproduction, hormonesensitive cancers in females, prostate cancer in males, thyroid, and neurodevelopment and neuroendocrine systems as being affected biological aspects of being exposed. The endocrine society s first scientific statement in 2009 provided a wakeup call to the scientific community abouthow environmental endocrine disrupting chemicals edcs affect health and disease. Executive summary to the endocrine societys 2nd scientific. Policy decisions on endocrine disruptors should be. Diamantikandarakis e1, bourguignon jp, giudice lc, hauser r, prins gs, soto am, zoeller rt, gore ac. Therefore, the endocrinedisrupting potential of a compound extends far beyond actions at hormone receptors, and testing paradigms and public policy must incorporate these aspects of edc exposure. December 20 key scientific statements on endocrine. Nov 10, 2015 increasing evidence supports the potential contribution of endocrine disrupting chemical edc exposure to the development of endocrine and metabolic disorders. In this first scientific statement of the endocrine society, we present the evidence that endocrine disruptors have effects on male and female reproduction. Endocrine disrupting chemicals edcs, a heterogeneous group of exogenous chemicals that can interfere with any aspect of endogenous hormones, represent an emerging global threat for human metabolism.
Scientific justification to address endocrine disrupting. Evanthia diamantikandarakis, jeanpierre bourguignon, linda c. The endocrine societys first scientific statement in 2009 provided a wakeup call to the scientific community abouthow environmental endocrinedisrupting chemicals edcs affect health and disease. Using the same format as the earlier wingspread statements, this group of. Sep 28, 2015 the statement builds upon the society s groundbreaking 2009 report, which examined the state of scientific evidence on endocrine disrupting chemicals edcs and the risks posed to human health.
There is growing interest in the possible health threat posed by endocrinedisrupting chemicals edcs, which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action resulting in. Endocrinedisrupting chemicals and risk of diabetes. There is growing interest in the possible health threat posed by endocrine disrupting chemicals edcs, which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action resulting in a deviation from normal homeostatic control or reproduction. Introduction to endocrine disrupting chemicals edcs. Endocrine disrupting chemicals are a group of pollutants that can affect the endocrine system and lead to diseases and dysfunctions across the lifespan of organisms.
Scientific knowledge about endocrinedisrupting chemicals edcs has been. She organized and chaired the gordon research conference on this topic 2012, as well as the endocrine societys first forum on endocrine disrupting chemicals 2005. Endocrine disrupting chemicals edcs are substances in the environment air, soil, or water supply. Some endocrinedisrupting chemicals are slow to breakdown in the environment.
Differences from the european union suggest the need for improved screening for chemical disruption to endocrine systems and proactive prevention. Consensus on the key characteristics of endocrinedisrupting. Scientific societies such as the endocrine society should partner with other organizations with the scientific and medical expertise to evaluate effects of endocrine disrupting chemicals in humans endocrine society statement diamantikandaris e et al. Jul 17, 2012 principles of endocrinology need to be applied to strengthen the safety assessment of endocrine disrupting chemicals edcs, a statement from the us endocrine society concludes. Endocrine disrupting chemicals what you need to know. Dec 22, 2014 several recent publications reflect debate on the issue of endocrine disrupting chemicals edcs, indicating that two seemingly mutually exclusive perspectives are being articulated separately and independently.
The endocrine societys first scientific statement in 2009 provided a wakeup call to the scientific community about how environmental endocrinedisr. The endocrine societys second scientific statement on endocrinedisrupting chemicals. There is growing interest in the possible health threat posed by endocrinedisrupting chemicals edcs, which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action resulting in a deviation from normal homeostatic control or reproduction. Endocrinedisrupting chemicals and the diabetes epidemic in.
Edc exposure in the usa contributes to disease and dysfunction, with annual costs taking up more than 2% of the gdp. Endocrine disrupting chemicalshow to strengthen safety. Several recent publications reflect debate on the issue of endocrine disrupting chemicals edcs, indicating that two seemingly mutually exclusive perspectives are being articulated separately and independently. Watch an animated overview to learn more and explore the rest of the societys education, resources, and advocacy campaigns on edcs. The endocrine society s first scientific statement in 2009 provided a wakeup call to the scientific community about how environmental endocrine disr. Endocrine disrupting chemicals edcs are chemicals that mimic, block, or interfere with hormones in the bodys endocrine system. On september 28, 2015 the endocrine society published the executive summary of the endocrine societys second scientific statement on endocrine disrupting chemicals fpf reported. Increasing evidence supports the potential contribution of endocrinedisrupting chemical edc exposure to the development of endocrine and metabolic disorders. Endocrinedisrupting chemicals edcs are substances in the environment air, soil, or water supply. That characteristic makes them potentially hazardous over time. They are defined as an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action.
Edcs comprise pesticides, fungicides, industrial chemicals, plasticizers, nonylphenols. Pcos is a debilitating disorder in women, occurring in 6. When functioning normally, the endocrine system works with other systems to regulate your bodys healthy development and function throughout life. In recent years, endocrine disrupting chemicals have gained interest in human physiopathology and more and more studies aimed to explain how these chemicals compounds affect endocrine system.
Endocrine disrupting chemicals edcs are a global problem for environmental and human health. Endocrinedisrupting chemicals an endocrine society scientific statement the endocrine society scientific statements are designed to educate basic scientists, clinical scientists, and clinicians concerning the scientific basis of disease and its application to the practice of medicine with regard to both prevention and management. Endocrine disrupting chemicals cause adverse effects in animals. This consensus statement on environmental endocrinedisrupting chemicals. Nov 01, 2016 the endocrine societys second scientific statement on environmental endocrinedisrupting chemicals, 1 edc2, was written by a group of basic scientists, clinical investigators, and environmental health experts brought together by the endocrine society. Endocrinedisrupting chemicals and public health protection.
Endocrinedisrupting chemicals pose global health threat. According to the endocrine society scientific statement, bisphenol a and other endocrine disrupting chemicals might contribute to the risk of polycystic ovary syndrome pcos in women. Endocrine disrupting chemicals edcs, a heterogeneous group of exogenous. Endocrine disrupting chemicals an endocrine society scientific statement the endocrine society scientific statements are designed to educate basic scientists, clinical scientists, and clinicians concerning the scientific basis of disease and its application to the practice of medicine with regard to both prevention and management. In human populations, the majority of the studies point toward an association between exposure to endocrine disrupting chemicals and the disorders affecting endocrine axis. The endocrine societys second scientific statement. An endocrine society scientific statement evanthia diamantikandarakis, jeanpierre bourguignon, linda c. An endocrine society scientific statement evanthia diamantikandarakis 1 endocrine section of first department of medicine e.
A precautionary approach to reducing american exposure to. There is now considerable evidence that the observed upsurge of metabolic disease cannot be fully attributed to increased caloric intake, physical inactivity, sleep deficit, and ageing. Neural, endocrine and behavioral effects 5 was produced under the auspices of the international school of ethology at the ettore majorana centre for scientific culture in erice. The endocrine societys first scientific statement in 2009 provided a wakeup call to the scientific community. Epa includes 85,000 chemicals, few of which are tested for health.
In terms of toxicity, the endocrine societys june 2009 scientific statement reads in part, results from animal models, human clinical observations, and epidemiological studies converge to implicate edcs endocrine disrupting chemicals as a significant concern to public health. Oct 21, 2015 she organized and chaired the gordon research conference on this topic 2012, as well as the endocrine societys first forum on endocrine disrupting chemicals 2005. Endocrinedisrupting chemicals edcs are chemicals that mimic, block, or interfere with hormones in the bodys endocrine system. Endocrine society issues scientific statement on obesitys. The endocrine system is a network of glands and organs that produce, store, and secrete hormones. There is growing interest in the possible health threat posed by endocrine disrupting chemicals edcs, which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action resulting in. Watch an animated overview to learn more and explore the rest of the society s education, resources, and advocacy campaigns on edcs. A path forward in the debate over health impacts of. A path forward in the debate over health impacts of endocrine. Statement calls for studying factors that undermine longterm weight maintenance a new scientific statement issued by the endocrine society calls for more research aimed specifically at understanding the underlying mechanisms that make it difficult to maintain longterm weight loss. This consensus statement on environmental endocrine disrupting chemicals.
Endocrinedisrupting chemicals edcs endocrine society. The endocrine society s second scientific statement on endocrine disrupting chemicals. Edcs comprise pesticides, fungicides, industrial chemicals, plasticizers. The connection between breast cancer and the environment. Principles of endocrinology need to be applied to strengthen the safety assessment of endocrine disrupting chemicals edcs, a statement from the us endocrine society concludes. They are in the air we breathe, in the food we eat and in the water we drink. The statement builds upon the societys groundbreaking 2009 report, which examined the state of scientific evidence on endocrinedisrupting chemicals edcs. Therefore, the endocrine disrupting potential of a compound extends far beyond actions at hormone receptors, and testing paradigms and public policy must incorporate these aspects of edc exposure. In this first scientific statement of the endocrine society, we present the evidence that endocrine disruptors have effects on male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology. In 2015 the endocrine society released a statement on endocrine disrupting chemicals edcs specifically listing obesity, diabetes, female reproduction, male reproduction, hormonesensitive cancers in females, prostate cancer in males, thyroid, and neurodevelopment and neuroendocrine systems as being affected biological aspects of being exposed.
Scientific statement on edcs published by the endocrine society. The endocrine societys second scientific statement on environmental endocrinedisrupting chemicals, 1 edc2, was written by a group of basic scientists, clinical investigators, and environmental health experts brought together by the endocrine society. It is estimated that there are about chemicals with endocrineacting properties. Sep 29, 2015 this second statement builds on the endocrine societys report of 2009, which examined the state of scientific evidence on endocrine disrupting chemicals edcs and their effects on human health. A statement of principles from the endocrine society. Our stolen future the book our stolen future, by theo colborn, dianne dumanoski and john peterson myers, brought worldwide attention to scientific discoveries about endocrine disruption. In this first scientific statement of the endocrine society, we present the evidence. Endocrine disrupting chemicals edcs are synthetic or natural compounds that can cause disease and dysfunction by interfering with the action of the natural hormones in the human body that regulate growth, development, reproduction and aging and influence risk of cancer. Endocrine society members have been at the forefront of scientific advancements in the field.